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Cortisone Injection And Flu Vaccine

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Are There Special Advantages In Using Cortisone Injections For Joint Inflammation

What To Know About This Season’s Flu Shots

Cortisone injections into a joint can be beneficial in rapidly reducing joint pain while restoring function to a body part immobilized by inflammation, such as an arthritic knee or elbow. This might be particularly important in certain circumstances, such as the gainful employment of a family breadwinner or someone who lives alone. Despite potential and infrequently reported adverse reactions as described above, it is generally felt that low, intermittent doses of corticosteroids pose little risk of significant side effects.

Cortisone injections into a joint also can decrease the inflammation in diseased joints throughout the body when the corticosteroids are absorbed from the joint into the circulation.

How Long Does A Cortisone Shot Last

How quickly the cortisone shot kicks in varies from person to person, but if your doctor mixes the medication with a numbing agent, you could feel relief within minutes. Otherwise, you could notice a difference in pain levels within a few hours or a few days, says Dr. Nesheiwat.

The same goes for how long cortisone shots last. For Dr. Nesheiwat, who got a cortisone shot herself in her elbow and continued to ice the area after she got the injection, the relief lasted roughly eight months. But, again, everyone is different, and a cortisone shot may last a few months in some people or a year in others, she says.

Differences Between Shot And Nasal Vaccine

People taking immunosuppressive drugs should get the flu shot, not the nasal-spray flu vaccine . LAIV, which contains live, weakened flu virus, is not recommended for anyone who has a chronic disease, including IBD. LAIV should also not be taken by anyone receiving medications that can weaken the immune system, such as the IBD drugs mentioned above.

The inactivated flu shot contains dead viruses and will not give the recipient the flu.

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Cortisone Steroid Injections And Covid Vaccination: Timing Is Everything

Howard J. Luks, MDUpdated November 6, 2021

Cortisone or steroid injections are utilized commonly by Orthopedic Surgeons, Rheumatologists, and Pain Management Physicians to manage inflammation and pain due to knee osteoarthritis, shoulder bursitis, back pain, and Rheumatoid disease. Cortisone, a form of steroid, can have effects on our immune function. Covid-19 vaccinations are taking place all around the globe. Tens of millions of vaccinations have already been administered. Do steroid injections interfere with the covid-19 vaccinations? Maybe.

How Should I Take Cortisone

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Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.

Your dose needs may change due to surgery, illness, stress, fever, or infection. Do not change your dose or stop using cortisone without your doctor’s advice.

cortisone can affect the results of certain medical tests. Tell any doctor who treats you that you are using cortisone.

Store at room temperature away from moisture, heat, and light.

Wear a medical alert tag or carry an ID card to let others know you take steroid medicine.

You should not stop using cortisone suddenly. Follow your doctor’s instructions about tapering your dose.

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What May Interact With This Medicine

  • chemotherapy or radiation therapy
  • steroid medicines like prednisone or cortisone
  • theophylline
  • vaccines

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What Should I Watch For While Using This Medicine

Report any side effects that do not go away within 3 days to your doctor or health care professional. Call your health care provider if any unusual symptoms occur within 6 weeks of receiving this vaccine.

You may still catch the flu, but the illness is not usually as bad. You cannot get the flu from the vaccine. The vaccine will not protect against colds or other illnesses that may cause fever. The vaccine is needed every year.

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Corticosteroid Injections Can Help Relieve Both Inflammatory Arthritis And Osteoarthritis Find Out More If Theyre A Good Pain Relief Option For You

Remember the Carly Simon song I Havent Got Time for the Pain? She may have been talking about heartbreak, but arthritis pain is something you dont want to make time for either. When you have osteoarthritis or a type of inflammatory arthritis, such as rheumatoid arthritis or gout, you may get used to living with daily chronic pain, but when an acute arthritis flare occurs, it can really throw you off your daily routine and ability to work, be active, run errands, etc. Thats where corticosteroid injections come in a treatment option for acute bouts of pain.

Before Cheryl Ackerman was diagnosed with rheumatoid arthritis, she was experiencing pain so excruciating that she could barely walk, sit, or stand for any length of time. Per a doctors recommendation, she received corticosteroid shots in both of her knees, neck, and back. After about three weeks I finally felt the full effect by the inflammation going down and this gave me great relief, says Ackerman, who is from Florida. Even with the maintenance and pain, Ackerman says getting the injections is worth it. They have improved my quality of life living with rheumatoid arthritis immensely.

Steroid injections can relieve pain and improve mobility for many people, but they dont work equally well for all types of arthritis. There are also important precautions about how frequently you can safely receive them. Heres what you need to know before you face the needle.

What Other Drugs Will Affect Dexamethasone

Get your flu shot today and help stop the spread of flu

Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective.

Many drugs can affect dexamethasone. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed here. Tell your doctor about all your current medicines and any medicine you start or stop using.

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Answers To Your Questions About Vaccines

You may search for additional questions and answers using keywords on the AAAAI Ask the Expert page.

Question: Could you please clarify the recommendations and considerations surrounding COVID-19 vaccination for individuals with persistently elevated tryptase levels. Early in the vaccination campaign there was conversation surrounding conditions with elevated tryptase and/or mast cell conditions being a vaccine contraindication but more recently I have not seen these recommendations persist.Our clinic has a patient who has had a persistently elevated tryptase level with several episodes of idiopathic anaphylaxis-type episodes. Work up suggests GPA/mast cell activation – consult with hematology suggests mast cell activation secondary to his autoimmune disorder or due to hypersensitive reaction) considered though bone marrow shows Normocellular bone marrow with mild nonspecific myeloid hypoplasia and no evidence of increased mast cell population.Answer: Individuals with mast cell activation syndrome or mastocytosis can be safely vaccinated with any of the approved COVID-19 vaccines and should be vaccinated.

A prophylactic dose of a non-sedating antihistamine prior to vaccination may improve acute tolerability.

Use Miralax dilutions for prick skin testing. Do not do any intradermal skin testing.

Step 1: Miralax 1:100

Step 2: Miralax 1:10

Step 3: Miralax 1:1

J Allergy Clin Immunol Pract. 2021 9:1765-66.

References:

Timing Of Musculoskeletal Cortisone Injections And Covid Vaccine Administration

AAOS Patient Safety Committee3/9/2021

The AAOS Patient Safety Committee recommends avoiding musculoskeletal corticosteroid injections for two weeks before and one week after COVID vaccine administration.

Musculoskeletal corticosteroid injections are common procedures which are most often performed in an elective, outpatient setting. These can include intra-articular, bursal, tendon, and neuraxial injections. Currently there is no direct evidence of the impact of corticosteroid injections on vaccine efficacy.

Corticosteroid injections have been shown to cause hypothalamic-pituitary-adrenal suppression. Increased risk of influenza infection has been associated with corticosteroids. It is unknown if corticosteroid injections could result in decreased immunogenicity which could reduce vaccine efficacy. The majority of musculoskeletal cortisone injections are elective procedures that can be safely postponed or rescheduled. Given the potential risk of diminished vaccine benefit, caution is appropriate.

When possible, surgeons should consider using shorter-acting corticosteroid medications and the lowest effective dose.

These recommendations are based on the best currently available clinical evidence and may be subject to update as more evidence is available.

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Timing And Spacing Of Immunobiologics

General Principles for Vaccine Scheduling

Optimal response to a vaccine depends on multiple factors, including the nature of the vaccine and the age and immune status of the recipient. Recommendations for the age at which vaccines are administered are influenced by age-specific risks for disease, age-specific risks for complications, ability of persons of a certain age to respond to the vaccine, and potential interference with the immune response by passively transferred maternal antibody. Vaccines are recommended for members of the youngest age group at risk for experiencing the disease for whom efficacy and safety have been demonstrated.

Approximately 90%–95% of recipients of a single dose of certain live vaccines administered by injection at the recommended age have protective antibody . For varicella and mumps vaccines, 80%–85% of vaccinees are protected after a single dose. However, because a limited proportion of recipients of measles-mumps-rubella or varicella vaccine fail to respond to 1 dose, a second dose is recommended to provide another opportunity to develop immunity . The majority of persons who fail to respond to the first dose of MMR or varicella vaccine respond to a second dose .

Spacing of Multiple Doses of the Same Antigen

Simultaneous Administration

Nonsimultaneous Administration

Spacing of Vaccines and Antibody-Containing Products

Live Vaccines

Inactivated Vaccines

Interchangeability of Vaccines from Different Manufacturers

Lapsed Vaccination Schedule

Alternatives To Cortisone Shots

Measles

If the big, scary needles of your childhood check-ups still haunt you, know that cortisone shots are just one of many tools in the shed. The biggest and best alternative: non-steroidal anti-inflammatory drugs, aka NSAIDS, says Dr. Nesheiwat. These drugsincluding over-the-counter varieties such as aspirin and ibuprofenhelp reduce inflammation, and thus pain, just as cortisone shots do. Plus, there are NSAID prescriptions used specifically to treat arthritis, bursitis, and tendonitiscommon inflammatory conditions that can be treated with cortisone shots, according to the Mayo Clinic.

Despite their ease of use, NSAIDs do come with a few drawbacks. They can relieve pain within a few hours, but it can take up to two weeks for the drug to reduce any swelling and inflammation in the joints, according to the Arthritis Foundation. And if you don’t take the NSAID with food, even just for a few doses, you could develop a stomach ulcer, says Dr. Nesheiwat. To combat this, she recommends patients who are taking an NSAID for an entire week or who have significant inflammation and are using a high-dose NSAID also take an over-the-counter stomach protector such as Pepcid.

You can also try acupuncture, which is believed to work by stimulating your bodys own healing mechanisms, explains Dr. Kim. Recent research has been positive and supportive in favor of its anti-inflammatory effects, and an increasing number of insurance plans are covering the procedure, he says.

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Steroid Injections And The Covid

Steroid injections are common procedures in primary care and outpatient settings. In most cases these injections are generally administered via an intra-articular, bursal, tendon or perineural approach with the most common indication being acute musculoskeletal pain.

There are a range of common side effects associated with this type of injection, including infection, post-injection flare and skin changes. These are generally well communicated to patients by their treating doctor. In addition to these âcommonâ side effects there is also a theoretical risk that administering an injection may diminish the immune response to the COVID-19 vaccine. It is important to consider this risk, whether it is clinically relevant and how to communicate this to patients.

There is no data that directly evaluates the impact of steroid injections on the efficacy of COVID-19 vaccinations. There is however some data from studies that looked at other vaccines and different routes of steroid administration. This has suggested that chronic high-dose steroids may impair vaccine-based immunity after the influenza vaccine. It should however be noted that the decrease of vaccine efficacy in this type of setting was small. Steroids given systemically in bolus format have not been demonstrated to impact vaccine efficacy.

The NHS
American Academy of Orthopaedic Surgeons
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American Society of Pain and Neuroscience

References:

What Types Of Doctors Administer Cortisone Injections

Many different health care professionals administer cortisone shots. The specialty administering the cortisone depends on the condition being treated. For example, a primary care doctor or nurse practitioner may administer a systemic cortisone injection in the gluteus muscle to treat an allergic reaction. Orthopedic surgeons commonly give cortisone injections into a joint, such as a cortisone injection into the knee to treat knee osteoarthritis. Dermatologists treat some skin conditions with special preparations of cortisone . Rheumatologists administer cortisone injections into joints to treat joint inflammation caused by rheumatoid arthritis or other forms of arthritis.

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Are The Shots Safe

Cortisone injections are extremely safe, but they do still have some risks.

Many healthcare providers will offer an injection as they are quick, easy, and usually work. Your healthcare provider should be able to provide other helpful treatments, though, if you cannot have or don’t want a cortisone shot.

If you have had side effects with cortisone shots in the past, be sure to let your healthcare provider know what condition was being treated and how severe the side effects were. This will inform decisions about whether or not you have another shot for the same or a different problem.

Complications From The Flu

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For some people, the flu can lead to the development of complications. People can die from complications of the flu, such as pneumonia. Common complications from the flu can include:

  • Bronchitis: Bronchitis is an infection of the airway that can cause a cough, wheezing, and fatigue. It may go away on its own in a few weeks, but it might also need treatment to resolve, especially if it’s caused by a bacteria that can be treated with antibiotics.
  • Ear infections: An infection inside the ear, which is also called otitis media, can occur after having the flu. Some of the symptoms include fever, ear pain, and dizziness or balance problems.
  • Pneumonia: Pneumonia is an infection in the lungs that can occur after having a cold or the flu. It can cause pain when breathing, cough with sputum, and fever. Pneumonia can be especially dangerous for the very young and the very old.
  • Sinus infections : In a common complication of the flu, the sinuses, which are located around the eyes, can become infected. Sinusitis can cause a headache or facial pain, fever, and sinus congestion. A sinus infection may need treatment, or it may resolve on its own.

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Steroid Injection Before Receiving The Covid

If you are planning on receiving the covid-19 vaccination, and you know the date that you will be vaccinated, then based on the available research and position statements from various organizations , you should wait up to 2-4 weeks after you receive a cortisone or steroid injection before having a covid-19 vaccine. The exact amount of time will depend on which steroid you are receiving and the dose you will receive. Talk this over with your doctor. If you received a cortisone injection, then you received a vaccination, do not panic. No data shows you will not generate a response to the vaccination. There is a chance that you might generate a lesser response. Again, the data isnt in yet.

Efficacy Of Vaccination In The Setting Of Systemic Steroid Use

The primary concern regarding COVID-19 vaccines in the setting of steroid use is efficacy given the immunosuppressive hallmarks of corticosteroids. These include direct effects on critical components of vaccine-based immunity, such as antigen presentation, T/B cell function and antibody generation. Almost 50 years ago, some of the first observations of steroids on the adaptive B cell responses, the primary mechanism of vaccine protection, were described by Dr. Anthony Fauci and colleagues. These included transient declines in lymphocyte populations with supraphysiologic dosing,, lymphocytic apoptosis, predominantly T cell, and altered immunoglobulin secretion,, and either suppression or stimulation. There exists considerable evidence in animal models that corticosteroids can influence both B cell development and function once in the periphery, although the implications of such on vaccine responses are not clear.

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Abbreviations Used In This Publication

AAFP American Academy of Family Physicians

AAP American Academy of Pediatrics

ACIP Advisory Committee on Immunization Practices

DT pediatric diphtheria-tetanus toxoid

DTaP pediatric diphtheria and tetanus toxoids and acellular pertussis vaccine

DTP pediatric diphtheria and tetanus toxoids and whole-cell pertussis vaccine

EIA/ELISA enzyme immunoassay

FDA Food and Drug Administration

HBIG hepatitis B immune globulin

HbOC Haemophilus influenzae type b-diphtheria CRM197 protein conjugate

HBsAg hepatitis B surface antigen

Hib Haemophilus influenzae type b

HIV human immunodeficiency virus

HSCT hematopoietic stem cell transplant

IgG immunoglobulin G

Tdap Tetanus reduced diphtheria acellular pertussis vaccine for adolescents and adults

TST tuberculin skin test

VAERS Vaccine Adverse Event Reporting System

VAPP vaccine-associated paralytic poliomyelitis

VICP Vaccine Injury Compensation Program

VIS Vaccine Information Statement

How Are Cortisone Injections Into A Joint Given

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The method of administering a cortisone injection into a joint is similar to that of soft-tissue injections. Betadine, however, is more commonly used for sterilization of the skin over the joint. This is an important precaution to prevent introducing infection into the joint. Furthermore, if there is an excessive amount of fluid within the joint, it often is removed first with a separate syringe and needle prior to injection of the cortisone. Removal of this joint fluid allows the doctor to examine the fluid and submit a sample to the laboratory for diagnosis. Removal also rapidly relieves pain by reducing the pressure in the fluid-filled joint. Finally, removal of fluid may allow the joint to heal more quickly. After a health care professional removes the fluid, he or she injects the cortisone medication into the joint, sometimes along with an anesthetic such as lidocaine or bupivacaine . Some health care professionals use an ultrasound to guide the needle into the exact location desired prior to injecting the cortisone into a joint .

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