Friday, September 29, 2023

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Description Of Trivalent Flublok Vaccine Clinical Studies Psc01 Psc03 Psc04 Psc06 And Psc11

Human trials of combo vaccine for COVID-19 and flu | 9 News Australia

Study PSC01 included 458 subjects, 18 through 49 years of age, for safety analysis, randomized to receive Flublok low dose , Flublok , or placebo .

Study PSC03 included 869 subjects aged 65 years and older for safety analysis, randomized to receive Flublok or another US-licensed trivalent influenza vaccine as an active control .

Study PSC04 included 4648 subjects, 18 through 49 years of age, for safety analysis, randomized to receive Flublok or placebo .

Study PSC06 included 602 subjects, 50 through 64 years of age, for safety analysis, randomized to receive Flublok or another US-licensed trivalent influenza vaccine .

Study PSC11 included 2627 subjects aged 50 years and older for safety analysis, randomized to receive Flublok or another US-licensed trivalent influenza vaccine as an active control . Among subjects 50 through 64 years of age, 672 received Flublok and 665 received Afluria. Among subjects aged 65 years and older, 642 received Flublok and 648 received Afluria.

How Effective Is The Flu Vaccine

The flu vaccine gives the best protection against flu.

Flu vaccines help protect against the main types of flu viruses, although there’s still a chance you might get flu.

If you do get flu after vaccination, it’s likely to be milder and not last as long.

Having the flu vaccine will also reduce the chance of you spreading flu to other people who may be more at risk of serious problems from flu.

It can take 10 to 14 days for the flu vaccine to work.

Flu & People 65 Years And Older

On June 30, 2022, CDC announced that Director Rochelle P. Walensky adopted the Decision memo approving the ACIP vote for a preferential recommendation for the use of higher dose or adjuvanted flu vaccines over standard-dose unadjuvanted flu vaccines for adults 65 years and older. CDCs full recommendations for the use of flu vaccines during 2022-2023 will appear in a forthcoming Morbidity and Mortality Weekly Report. Edits to this page are also forthcoming. More information can be found online: CDC Director Adopts Preference for Specific Flu Vaccines for Seniors

People 65 years and older are at higher risk of developing serious flu complications compared with young, healthy adults. This increased risk is due in part to changes in immune defenses with increasing age. While flu seasons vary in severity, during most seasons, people 65 years and older bear the greatest burden of severe flu disease. In recent years, for example, its estimated that between 70 percent and 85 percent of seasonal flu-related deaths have occurred in people 65 years and older, and between 50 percent and 70 percent of seasonal flu-related hospitalizations have occurred among people in this age group.

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Where To Get The Flu Vaccine

You can have the NHS flu vaccine at:

  • your GP surgery
  • a pharmacy offering the service
  • your midwifery service if you’re pregnant
  • a hospital appointment

If you do not have your flu vaccine at your GP surgery, you do not have to tell the surgery. This will be done for you.

It’s important to go to your vaccination appointments unless you have symptoms of COVID-19.

Hcp Fight Flu Toolkit

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Whether youre a primary care physician, nurse, pharmacist, or other health care professional , you play a significant role in helping protect your patients against influenza. The best available protection is annual influenza vaccination for all patients ages 6 months and older. Your strong influenza vaccine recommendation is one of the most important factors in patients accepting the vaccine.

This page provides tools to prepare your practice to fight flu. The materials will:

  • Equip you to make strong influenza vaccine recommendations
  • Facilitate productive conversations with your patients
  • Improve your influenza vaccination rates

These fact sheets provide information on the timing and types of influenza vaccinations as well as methods to provide a strong influenza vaccine recommendation to parents, adults ages 50-64, adults ages 65+, and the general public.

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Flu Vaccine And Coronavirus

Flu vaccination is important because:

  • more people are likely to get flu this winter as fewer people will have built up natural immunity to it during the COVID-19 pandemic
  • if you get flu and COVID-19 at the same time, research shows you’re more likely to be seriously ill
  • getting vaccinated against flu and COVID-19 will provide protection for you and those around you for both these serious illnesses

If you’ve had COVID-19, it’s safe to have the flu vaccine. It will still be effective at helping to prevent flu.

Over 50s To Be Offered Covid

Everyone aged 50 and over will be among those offered a COVID-19 booster and a flu jab this autumn under plans to increase protection against respiratory viruses ahead of winter.

From:
15 July 2022 See all updates

On coronavirus boosters, the Joint Committee on Vaccination and Immunisation has now published its final recommendations for this autumns programme.

Under the advice, those eligible for a further dose will be:

  • all adults aged 50 years and over
  • those aged 5 to 49 years in a clinical risk group, including pregnant women
  • those aged 5 to 49 years who are household contacts of people with immunosuppression
  • those aged 16 to 49 years who are carers
  • residents in a care home for older adults and staff working in care homes for older adults
  • frontline health and social care workers

In addition, the Department of Health and Social Care will be widening the offer of the free flu vaccine to more eligible groups. These additional groups will only be eligible once the most vulnerable, including previously announced pre-school and primary school children, those aged 65 years and over and those in clinical risk groups, have been offered the jab.

The additional groups set to be offered the free flu vaccine in England will be:

  • all adults aged 50 to 64 years
  • secondary school children in years 7, 8 and 9, who will be offered the vaccine in order of school year

People in these groups are asked not to come forward until further information is announced.

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Which Older Adults Are Getting Their Flu Shots And Covid Boosters

Poll shows majority of people over 50 have already gotten or intend to get both, with a higher likelihood among those over 65.

With two viruses threatening to make older adults sick this winter, a new poll shows most people over 50 have gotten vaccines to protect them against both influenza and coronavirus, or plan to. And a majority of those who have gotten the COVID-19 vaccine plan to get an additional dose to boost their level of protection.

But the poll, taken in mid-October, also reveals major differences in vaccine attitudes between older adults of different age groups, racial and ethnic backgrounds, and other characteristics including personal political leaning.

The new findings come from the National Poll on Healthy Aging, based at the University of Michigan Institute for Healthcare Policy and Innovation, and supported by AARP and Michigan Medicine, U-Ms academic medical center.

The poll finds that 1 in 3 older adults feel it is more important to get vaccinated against the flu this year than in years before the COVID-19 pandemic. Almost all of the rest said the importance this year is the same.

If You’re Ages 50 To 64

Texans Between 50 And 64 Now Eligible For Coronavirus Vaccine

The choices include the regular flu shot, the new quadrivalent flu shot, the tiny-needle shot and the egg-free Flucelvax.

Should I get the quadrivalent vaccine?

For somewhat younger adults, the quadrivalent shot may be ideal in terms of protection against flu. But here as well, studies have yet to prove superior performance over regular vaccine. And because it’s brand new this year, supplies are limited. Zimmerman says that if all the alternatives were offered at the same price, for people 50 to 64 he’d choose the quadrivalent vaccine. “However, I would not travel an extra 20 minutes for it,” he adds.

Is the tiny-needle shot a good option?

Those wary of needles can also opt for the tiny-needle or “intradermal” shot, which deposits the medicine under the skin rather than in the muscle, as a standard shot does. It’s been approved for people ages 18 to 64 and protects against three viral strains, same as the standard flu shot. It also can be harder to find than the standard flu shot.

What about the egg-free vaccine?

Anyone 18 or older who is hypersensitive to eggs a problem that’s actually far more common in young children can choose a vaccine whose virus is grown in mammalian cells rather than chicken eggs.

Katharine Greider is a freelance writer.

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Allergic Reactions To The Flu Vaccine

It’s very rare for anyone to have a serious allergic reaction to the flu vaccine. If this does happen, it usually happens within minutes.

The person who vaccinates you will be trained to deal with allergic reactions and treat them immediately.

Anyone can report a suspected side effect of a vaccine through the Yellow Card Scheme.

Who Should Not Have The Flu Vaccine

Most adults can have the flu vaccine, but you should avoid it if you have had a serious allergic reaction to a flu vaccine in the past.

You may be at risk of an allergic reaction to the flu vaccine injection if you have an egg allergy. This is because some flu vaccines are made using eggs.

Ask a GP or pharmacist for a low-egg or egg-free vaccine.

If you’re ill with a high temperature, it’s best to wait until you’re better before having the flu vaccine.

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If You’re Age 65 And Older

The choices include the regular flu shot , the high-dose flu shot , the quadrivalent flu shot and the egg-free shot called Flucelvax.

Should you get the high-dose vaccine or standard one?

Talk to your doctor about whether you need a high-dose vaccine, but studies do show that people who receive the high-dose vaccine produce more antibodies infection-fighting proteins in the blood than those who get the regular dose. That’s important because vaccines work by provoking the immune system’s defenses against the target disease, and older people tend to mount a weaker response.

In fact, the high-dose vaccine was developed to address concerns that the standard-dose shot doesn’t work very well in people 65 and older, the very group most likely to be hospitalized or die from flu complications. Last year, for example, the CDC reported that season’s regular vaccine lowered an older person’s risk of flu by only 27 percent, an unexpectedly low level of effectiveness compared with a 63 percent reduction for people ages 50 to 64.

Whether the high-dose shot’s effect on blood antibodies will translate into substantially fewer people getting sick is not yet clear. But signs are good that it offers at least some advantage. In August the vaccine’s maker, Sanofi Pasteur, issued preliminary findings from an ongoing clinical trial showing the higher dose increased flu prevention by 24 percent over the standard dose.

What about the new quadrivalent vaccine?

A Flu Vaccine Is The Best Protection Against Flu

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Flu vaccination has many benefits. It has been shown to reduce flu illnesses and also to reduce the risk of more serious flu outcomes that can result in hospitalization or even death in older people. Flu vaccination has been shown in several studies to reduce severity of illness in people who get vaccinated but still get sick.

The best way to protect against flu and its potentially serious complications is with a flu vaccine. CDC recommends that almost everyone 6 months and older get a seasonal flu vaccine each year, ideally by the end of October. However, as long as flu viruses are circulating, vaccination should continue throughout flu season, even into January or later.

Flu vaccination is especially important for people 65 years and older because they are at higher risk of developing serious flu complications. Flu vaccines are updated each season to keep up with changing viruses. Also, immunity wanes over a year so annual vaccination is needed to ensure the best possible protection against flu. Because immunity may decrease more quickly in older people, it is especially important that this group is not vaccinated too early . September and October are generally good times to be vaccinated for people 65 years and older.

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How To Book Your Appointment

If you’re eligible for a free flu vaccine, you can book an appointment at your GP surgery or a pharmacy that offers it on the NHS.

You may also get an invitation to get the vaccine, but you do not have to wait for this before booking an appointment.

Everyone who is eligible for the free flu vaccine will be able to get it.

GP surgeries and pharmacies get the flu vaccine in batches. If you cannot get an appointment straight away, ask if you can book an appointment for when more vaccines are available.

If you have an appointment for a COVID-19 booster vaccine at a GP surgery or pharmacy, you may also be offered a flu vaccine at the same time.

Do not delay booking your flu vaccine appointment so that you can get both vaccines together. Only some people will be offered both vaccines at the same time.

More Findings From Older Adults Polled About Both Flu Shots And Covid Vaccines

Last years flu shot:

  • In all, 54% of people between the ages of 50 and 64 say they got a flu shot last year, much lower than the 83% of those over 65 who said they did.

  • There werent major differences in 2020 flu shots by gender, race/ethnicity, income or living situation, but there were based on political party identification. Those living in the South were also less likely that those in other regions to have had a flu shot in 2020.

This years flu shot:

  • Sixty-four percent of people between the ages of 50 and 64 say theyve already gotten their flu shot this year or theyre likely to, while 86% of those over 65 say they already have or are likely to.

  • Those over 65 were nearly twice as likely as those aged 50 to 64 to have already gotten their flu shot by the time the poll was taken in mid-October .

  • Most of respondents who identified as Democrats said they had already had a flu shot or planned to get one, compared with 67% of Republications and 60% of independents.

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Flu Vaccine For Frontline Health And Social Care Workers

If you’re a frontline health and social care worker, your employer should offer you a flu vaccine. They may give the vaccine at your workplace.

You can also have an NHS flu vaccine at a GP surgery or a pharmacy if:

  • you’re a health or social care worker employed by a registered residential care or nursing home, registered homecare organisation or a hospice
  • you work in NHS primary care and have direct contact with patients this includes contractors, non-clinical staff and locums
  • you provide health or social care through direct payments or personal health budgets, or both

Safety And Side Effects

More Than 50% Of People With Chronic Health Conditions Neglect Their Flu Shots

The inactivated flu vaccine does not contain the live virus and cannot cause flu. Flu vaccines have a very good safety record. The most commonly reported side effects of flu vaccines are:

  • pain, swelling, bruising, hardness or redness at the injection site
  • slightly raised temperature
  • tiredness
  • feeling generally unwell

A higher rate of these common side effects has been reported with Fluad, an adjuvanted trivalent vaccine which was recommended for people aged 65 and over in previous years. This year, a quadrivalent inactivated influenza vaccine which also uses an adjuvant is being offered to people aged over 65. Side effects usually last 1-3 days.

There are several different makes of flu vaccine available each year. For more information on side effects, ask for the Patient Information Leaflet for the vaccine you are offered. Additional information about vaccine side effects, anaphylaxis and adverse reactions can be found here.

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How Effective Is The Nhs Flu Immunisation Programme

The flu vaccine works better in some years than others . Across all age groups including children, the flu vaccine prevented 15-52% of flu cases between 2015 – 2020 . Due to low levels of circulating influenza in the 2020-21 flu season, it has not been possible to determine vaccine effectiveness for this time period.

Protection from the flu virus varies for different age groups. In children aged 2-17, the flu vaccine prevented 66% of flu cases in 2016-17, 27% of flu cases in 2017-18, and 49% of flu cases in 2018-19. However, in the over 65 age group the inactivated flu vaccine worked less well than it did in other adults and children. In 2016-17, the data suggest that the inactivated flu vaccine did not work at all in people aged over 65, whilst in 2017-2018 it resulted in slightly better results in that age group. Due to the lower effectiveness of the inactivated flu vaccine in older people, a vaccine containing an adjuvant was introduced for the 2018-19 season. This is a substance that strengthens and lengthens the immune response to the vaccine and resulted in better prevention of flu in people aged 65 or over in flu seasons since 2018-19. The adjuvanted vaccine is still recommended for this age group in the 2022-23 season.

It is not understood why flu vaccines do not work so well in older adults. However, this reinforces the importance of vaccinating children and healthcare workers, both of whom can help to stop the spread of flu to older adults.

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