So It Offers More Protection From The Flu
Exactly. A 2014 study published in The New England Journal of Clinical Medicine, which involved more than 30,000 adults aged 65 and older, found that participants who received the high-dose flu vaccine had 24% fewer flu illnesses compared to those who got the standard flu vaccine.
Another study, carried out during the 2013-2014 flu season and published in The Lancet Respiratory Medicine in 2017, found that the high-dose flu shot was associated with a lower risk of hospital admissions compared with the regular flu shot in people age 65 and over. This was particularly true for those living in long-term care facilities.
Will Getting Fluzone Make Me Get The Flu
No. Flu vaccines that are given with a needle, such Fluzone, contain inactivated influenza virus. Inactivated viruses arent live, so they wont make you sick.
When you get an inactivated flu vaccine, your immune system gets exposed to the inactivated flu virus. This prompts your immune system to make antibodies against the strains of flu contained in the vaccine. Once you have antibodies to the flu, if youre exposed to it, your body will be more prepared to fight it off.
On the other hand, the nasal flu vaccine, called FluMist, is made using a weakened form of a live flu virus. The live virus contained in FluMist can only reproduce and spread at cool temperatures, such as those found in your nose. It cant spread infection to your lungs, for example. So when the virus is contained to your nose, it shouldnt cause a flu infection in your body.
But its possible that FluMist may cause side effects that are similar to symptoms caused by the flu. These side effects, which may occur for up to a few days after you get FluMist, include:
- runny nose
What Is The Cost Of The Flu Shot
You may have concerns about the cost of getting an annual flu vaccination. The cost varies depending on where you go and whether you have insurance. In some cases, you may be able to get the flu shot free of charge or at a low cost.
Typical prices for the adult flu vaccine range between $0 and $40 , depending on the vaccine you receive and your insurance coverage.
Ask your doctor about getting the flu shot during an office visit. Some pharmacies and hospitals in your community may provide vaccinations. You can also research flu clinics at community centers or senior centers.
Note that some of the typical providers like schools and workplaces may not offer them this year due to closures during the COVID-19 pandemic.
Use websites like Vaccine Finder to find locations near you that offer the flu vaccine, and contact them to compare costs.
The sooner you get a vaccination, the better. On average, it can take up to 2 weeks for your body to produce antibodies to protect against the flu. The Centers for Disease Control and Prevention recommends getting a flu shot by the end of October.
Iv4 Simultaneous Administration With Other Vaccines
In general, NACI recommends that two live parenteral vaccines be administered either on the same day or at least 4 weeks apart Footnote 166. This recommendation is based largely on a single study from 1965 that demonstrated immune interference between smallpox vaccine and measles vaccine administered 9-15 days apart. Subsequent studies have revealed conflicting results on immune interference between live vaccinesFootnote 167, Footnote 168, Footnote 169Footnote 170. No studies were found on potential immune interference between LAIV and other live attenuated vaccines administered within 4 weeks. A few studies on concomitant administration of LAIV3 with MMR, varicella, and oral polio vaccines did not find evidence of clinically significant immune interferenceFootnote 10, Footnote 12, Footnote 13. One study reported a statistically significant but not clinically meaningful decrease in seroresponse rates to rubella antigen when administered concomitantly with LAIV.
Table 1 Influenza Vaccines United States 202021 Influenza Season*
|Trade name||HA or virus count for each vaccine virus||Route|
|Standard dose, cell culture based|
|High dose, egg based|
|Fluzone High-Dose Quadrivalent|
|Standard dose, egg based with MF59 adjuvant|
|Standard dose, egg based with MF59 adjuvant|
|0.2-mL prefilled single-use intranasal sprayer||2 through 49 yrs||106.5-7.5 fluorescent focus units/0.2 mL||NAS|
Abbreviations: ACIP = Advisory Committee on Immunization Practices FDA = Food and Drug Administration HA = hemagglutinin IIV3 = inactivated influenza vaccine, trivalent IIV4 = inactivated influenza vaccine, quadrivalent IM = intramuscular LAIV4 = live attenuated influenza vaccine, quadrivalent MDV = multidose vial NAS = intranasal PFS = prefilled syringe RIV4 = recombinant influenza vaccine, quadrivalent SDV = single-dose vial.
* Vaccination providers should consult FDA-approved prescribing information for 202021 influenza vaccines for the most complete and updated information, including indications, contraindications, warnings, and precautions. Package inserts for U.S.-licensed vaccinesexternal icon. Availability and characteristics of specific products and presentations might change and/or differ from what is described in this table and in the text of the full report.
§ The dose volume for Afluria Quadrivalent is 0.25 mL for children aged 6 through 35 months and 0.5 mL for persons aged 3 years.
People At High Risk Of Influenza
- All children 6 to 59 months of age
- Adults and children with the following chronic health conditions:
- cardiac or pulmonary disorders
- diabetes mellitus and other metabolic diseases
- cancer, immune compromising conditions due to underlying disease, therapy, or both, such as solid organ transplant or hematopoietic stem cell transplant recipients
- renal disease
- neurologic or neurodevelopment conditions, including:
- seizure disorders
What Are Flu Vaccines For Seniors
Often referred to as High-Dose , based on the brand name of one popular flu vaccine, flu vaccines for seniors are super-charged to help keep people 65+ healthy throughout the flu season. The two approved vaccines for people 65+ either contain four times the antigens of a regular flu shot or an additive known as an adjuvant.
Both offer greater, but about the same as one another, protection from illness than standard egg-based quadrivalent vaccines, studies have shown.
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Table Influenza Vaccines United States 202122 Influenza Season*
|µg HA or virus count for each vaccine virus||Route|
|0.2-mL prefilled single-use intranasal sprayer||2 through 49 yrs||
106.57.5 fluorescent focus units/0.2 mL
Abbreviations: ACIP = Advisory Committee on Immunization Practices FDA = Food and Drug Administration HA = hemagglutinin IIV4 = inactivated influenza vaccine, quadrivalent IM = intramuscular LAIV4 = live attenuated influenza vaccine, quadrivalent MDV = multidose vial mos = months NAS = intranasal PFS = prefilled syringe RIV4 = recombinant influenza vaccine, quadrivalent SDV = single-dose vial
* Vaccination providers should consult FDA-approved prescribing information for 202122 influenza vaccines for the most complete and updated information, including indications, contraindications, warnings, and precautions. Package inserts for U.S.-licensed vaccines are available at . Availability and characteristics of specific products and presentations might change or differ from what is described in this table and in the text of this report.
§The dose volume for Afluria Quadrivalent is 0.25 mL for children aged 6 through 35 months and 0.5 mL for persons aged 3 years.
Use The Following Questionsto Find Out More From Your Doctor Or Pharmacist:
Indication and Safety Information:
FLUZONE® High-Dose Quadrivalent
FLUZONE® High-Dose Quadrivalent is a vaccine used to prevent influenza in adults 65 years of age and older. Influenza is an infection caused by the influenza virus. Annual vaccination using the current vaccine is recommended for prevention against influenza as immunity declines in the year following vaccination and because circulating strains of influenza virus change from year to year. Persons with a history of severe allergic reaction to eggs or egg products or any component of FLUZONE® High-Dose Quadrivalent should not receive the vaccine. FLUZONE® High-Dose Quadrivalent will only protect against the strains of influenza virus for those that are closely related. FLUZONE® High-Dose Quadrivalent will not protect against any other strains of influenza virus. FLUZONE® High-Dose Quadrivalent is not indicated for the prevention of hospitalization or death or to reduce the risk of complications after the onset of disease. As with all vaccines, FLUZONE® High-Dose Quadrivalent does not protect 100% of people immunized. The most common side effects are pain at the injection site, muscle ache. Allergic reactions can occur. Contact your healthcare provider to see if this vaccine is right for you. For more information, visit www.sanofi.ca.
This website is for Canadian residents only.
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What Other Flu Vaccines Are Available For People 65 Years And Older
In addition to Fluzone High-Dose Quadrivalent, one other influenza vaccine is licensed specifically for people 65 years and older. The adjuvanted flu vaccine,FLUAD Quadrivalent, external icon contains an adjuvant, an ingredient intended to help improve immune response.
One recombinant influenza vaccine, Flublok Quadrivalent , is available during the 20202021 influenza season. Flublok Quadrivalent was first licensed by the FDA in the United States for use in adults 18 years and older in 2017. An earlier trivalent version was licensed in 2013 but was later replaced by the quadrivalent version. A new CDC study showed that flu shots made using recombinant technology produced a better antibody response among health care personnel compared with both cell-based and traditional flu shots.
Iii2 People Capable Of Transmitting Influenza To Those At High Risk Of Influenza
People who are potentially capable of transmitting influenza to those at high risk should receive annual vaccination, regardless of whether the high-risk individual has been vaccinated. Vaccination of HCWs decreases their own risk of illnessFootnote 52,Footnote 53, as well as the risk of death and other serious outcomes among the individuals for whom they provide careFootnote 54,Footnote 55,Footnote 56,Footnote 57. Vaccination of HCWs and residents of nursing homes is associated with decreased risk of ILI outbreaksFootnote 58.
People who are more likely to transmit influenza to those at high risk of influenza-related complications or hospitalization include:
- HCWs and other care providers in facilities and community settings who, through their activities, are capable of transmitting influenza to those at high risk and
- Contacts, both adults and children, of individuals at high risk, whether or not the individual at high risk has been vaccinated.
Health care workers and other care providers in facilities and community settings
Vaccination of health care workers and other care providers
Outbreak management in health care facilities
Contacts of individuals at high risk of influenza complications
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What Age Do I Need To Be To Take Fluzone
This depends on the form of Fluzone youre taking:
- Fluzone Quadrivalent is approved for use in people ages 6 months and older.
- Fluzone High-Dose Quadrivalent is approved for use in adults ages 65 years old and older.
For more information on which form of Fluzone you should take based on your age, see the Fluzone dosage section above. And if you have additional questions about which flu vaccine is best for you, talk with your doctor or pharmacist.
Dose And Method Of Administration
Fluzone High-Dose Quadrivalent should be given in accordance with the national recommendation as per the current Immunisation Handbook.The recommended dosage of Fluzone High-Dose Quadrivalent is 1 dose of 0.7 mL, annually, in persons 60 years of age and older.Administration should be carried out by intramuscular route.Injections of Fluzone High-Dose Quadrivalent should be administered intramuscularly, preferably in the deltoid muscle. The vaccine should not be injected into the gluteal region, or into areas where there may be a major nerve trunk.For needle size and length, refer to the national recommendations as per the current Immunisation Handbook.Do not administer this product intravenously.Shake before use to distribute suspension uniformly before administration.Parenteral drug products should be inspected visually for particulate matter and/or discoloration prior to administration whenever solution and container permit. If either of these conditions exists, the vaccine should not be administered.The syringe is for single use only and must not be reused. Discard any remaining unused contents.
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Interactions With Other Medicines And Other Forms Of Interactions
Fluzone High-Dose Quadrivalent should not be mixed with any other vaccine in the same syringe or vial.There are no data to assess the concomitant administration of Fluzone High-Dose Quadrivalent with other vaccines. Refer to the current Immunisation Handbook for more information.If Fluzone High-Dose Quadrivalent is to be given at the same time as another injectable vaccine, the vaccines should always be administered at different injection sites.If the vaccine is used in individuals deficient in producing antibodies due to immunosuppressive therapy, the expected immune response may not be obtained.
Dosage Of Fluzone Quadrivalent
Fluzone Quadrivalent is approved to protect against influenza in people ages 6 months and older. For people ages 9 years and older, the recommended dose for this use is one 0.5-mL injection of the vaccine.
For dosage information for people younger than 9 years of age, see the Pediatric dosage section just below.
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I1 New Or Updated Information For 2020
NACI recently reassessed the wording for the recommendation on the vaccination of health care workers and other care providers as a group for whom influenza vaccination is particularly recommended. The existing evidence on HCW influenza vaccination and the reduction of morbidity associated with influenza in patients being cared for by a HCW in health care settings was considered in the context of ethics and acceptability. NACI continues to recommend that, in the absence of contraindications, HCWs and other care providers in facilities and community settings should be vaccinated annually against influenza, and recommends the inclusion of this group among the particularly recommended recipients of influenza vaccine. NACI considers the receipt of influenza vaccination to be an essential component of the standard of care for all HCWs and other care providers for their own protection and that of their patients. This group should consider annual influenza vaccination as part of their responsibilities to provide the highest standard of care.
Recommendation on the use of LAIV in HIV-infected individuals
Naci Influenza Working Group
Members: I Gemmill , L Cochrane, N Dayneka, R Harrison, K Klein, D Kumar, J Langley, J McElhaney, A McGeer, D Moore, S Smith, and B Warshawsky.
Former member: M Lavoie.
Liaison representatives: L Grohskopf .
Ex-officio representatives: C Bancej , P Wolfe-Roberge , and J Xiong .
Former ex-officio representative: K Watkins .
Iv5 Additional Vaccine Safety Considerations
Influenza vaccine is safe and well tolerated. Contraindications, precautions, and common AEs are described in Section II. Additional information regarding egg-allergic individuals and GBS is provided below.
After careful review of clinical and post-licensure safety data, NACI has concluded that egg-allergic individuals may be vaccinated against influenza using any appropriate product, including LAIV, without prior influenza vaccine skin test and with the full dose, irrespective of a past severe reaction to egg and without any particular consideration, including vaccination setting. The amount of trace ovalbumin allowed in influenza vaccines that are authorized for use in Canada is associated with a low risk of AE. The observation period post-vaccination is as recommended in Vaccine Safety in Part 2 of the CIG. As with all vaccine administration, vaccine providers should be prepared with the necessary equipment, knowledge, and skills to respond to a vaccine emergency at all times.
Refer to the Statement on Seasonal Influenza Vaccine for 2018-2019 for safety data supporting this recommendation for IIV and LAIV.
Vaccines For Use In Under 65s
Three vaccine brands are being supplied under the NIP in 2022 for people aged under 65 years who are in the following at risk groups: Aboriginal and Torres Strait Islander people, pregnant women, and people who have certain medical conditions: Vaxigrip Tetra, Fluarix Tetra and Afluria Quad. Vaxigrip Tetra and Afluria Quad are registered for all people under the age of 65 years.
Influvac Tetra and Fluquadri are also registered for use in people under the age of 65 years, however both will be available for purchase on the private market only.
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Iv2 Live Attenuated Influenza Vaccine
LAIV contains standardized quantities of FFU of live attenuated influenza virus reassortants. The virus strains in LAIV are cold-adapted and temperature sensitive, so they replicate in the nasal mucosa rather than the lower respiratory tract, and they are attenuated, so they do not produce ILI. There have been no reported or documented cases, and no theoretical or scientific basis to suggest transmission of vaccine virus would occur to the individual administering LAIV. As a live replicating whole virus formulation administered intranasally, it elicits mucosal immunity, which may more closely mimic natural infection.
Vaccine currently authorized for use:
- FluMist® Quadrivalent
Efficacy and effectiveness
After careful review of the available Canadian and international LAIV VE data over many influenza seasons, NACI concluded that the current evidence is consistent with LAIV providing comparable protection against influenza to that afforded by IIV and does not support a recommendation for the preferential use of LAIV in children 2-17 years of age.
Refer to the Statement on Seasonal Influenza Vaccine for 2018-2019 for detailed information supporting this recommendation.
LAIV4 has shown non-inferiority based on immunogenicity compared to LAIV3 in both children and adults. The immune response to the B strain found only in the quadrivalent formulation was better in children who received the quadrivalent vaccine Footnote 158, Footnote 159, Footnote 160.